Proponent(s)
Joseph Gudelos
Abstract
This article provides a comprehensive patent landscape analysis of nanotechnology-driven drug delivery systems for Huntington's Disease (HD) between 2014 and 2024, based on 717 patent records retrieved from the Lens.org database. HD remains an incurable neurodegenerative disorder with no effective treatment, thus becoming one of the most compelling needs in innovative therapeutic solutions. The present study fills the extant gaps in the literature and geographical concentration of research in North America and Europe, the underrepresentation of regions with a lower prevalence of HD, and no broader socioeconomic assessment of technological innovations. In addition, the transition of nanotechnology-driven systems from preclinical to clinical applications requires addressing challenges of scale, safety, efficacy, and long-term outcomes. Using patent analytics, this study identified key trends of patent activity, innovation patterns, contributors, geographical distribution, citation impact, and technological focus areas. A targeted search was made for patents related to nanotechnology-based drug delivery systems for HD published between January 2014 and January 2024. It was found that the number of patent filings has considerably increased, while the United States leads in innovation and key contributors such as MIT and Zhang Feng have played important roles in advancing the field. The technological attention is paid to overcoming the blood-brain barrier using nanotechnology and combining gene therapies-approaches like CRISPR-Cas9-in one treatment. These areas promise, while setbacks such as off-target effects and delivery mechanisms still confront gene therapies. Also, the region depicts the differences in their area of research activities while in need of a real review about how much novelty can be used in the field and how costly that one is. The findings are of immense value in understanding the evolution of the patent landscape, bringing to light emerging trends, key contributors, and areas for future research and collaboration, and guiding efforts to advance nanotechnology-driven solutions for HD treatment and to improve global access.
Publication Date
February 01, 2025
Name of Research Journal
International Journal of Research and Scientific Innovation
ISSN / ISBN
ISSN: 2321-2705
Volume and Issue No.
Vol. 12, Issue 1
Citation
Gudelos, J. (2025). Patent Database Analysis on Nanotechnology-Driven Drug Delivery Systems for Huntington's Disease. Available at SSRN 5162933.
